Several
studies have illustrated a link between SLS-free
toothpastes and a reduction in canker sores. Here we list
the abstracts from two of these hallmark clinical
studies. An abstract is the summarization that appears at
the beginning of the paper reporting on the clinical
trial.
dentrifice =
toothpaste
RAU = Recurrent Aphthous Ulcer =
canker sores
Chahine, L., Nancy, S. and C. Wagoner THE
EFFECT OF SODIUM LAURYL SULFATE ON RECURRENT APHTHOUS
ULCERS: A CLINICAL STUDY, Compendium 1997; 18(12) pgs
1238-1240
Abstract: This study measured the incidence
of recurrent aphthous ulcers during the use of
dentrifices with and without sodium lauryl sulfate
(SLS). A single-blind crossover design was used. A
statistically significant reduction in the recurrent
aphthous ulcers was observed during 2 months' use of
SLS-free dentrifice compared to to 2 months' use of
SLS-containing dentrifice. These results support the
results of an earlier independent study, and suggest
that use of an SLS-free dentrifice should be
considered for individuals suffering from recurrent
aphthous ulcers.
Herlofson, B.B. and P. Barkvoll SODIUM
LAURYL SULFATE AND RECURRENT APHTHOUS ULCERS: A
PRELIMINARY STUDY Acta Odontol Scand 1994; 52 pgs.
257-259
Abstract: Sodium lauryl sulfate (SLS), a
synthetic detergent commonly used in dentrifices, is
an effective denaturant. The aim of the present study
was to investigate the effect of SLS in patients with
recurrent aphthous ulcers (RAU). Ten patients with
multiple minor RAU participated in the study. The
mean incidence of RAU was 17.8 during a 3-month
period before the study. The patients used a
dentrifice containing 1.2% SLS for a test period of 3
months followed by a dentrifice without SLS for the
same time period. The results showed a statistically
significant decrease in the number of aphthous ulcers
from 14.3 after using SLS-containing dentrifice to
5.1 ulcers after brushing with the SLS-free
dentrifice (p
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educational purposes only. It is not meant to serve as
delivery of medical care. Those persons with specific
medical questions should consult their dentist, doctor,
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